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Please click this button for all publications from Parashar laboratory

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How does a second messenger regulate a histidine kinase for virulence?

Dr Dutta's paper on KdpD Histidine kinase interaction with a second messenger c-di-AMP shows how a structurally distinct universal stress protein domain in KdpD senses c-di-AMP. Read this paper in the Journal of Biological Chemistry 

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How does a second messenger unite two CRISPR systems for viral defense? 

Mr Pengjun Xia's paper on how bacterial second messenger cA4 regulation of  Csa3 transcription factors outlines crosstalk between type-I and type-III CRISPR systems for viral defense. Read this paper in the Journal of Biological Chemistry 

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How to specifically visualize single circular RNAs in situ ?

Mr Aakash Koppula's paper development of a new single-molecule imaging method for circular RNAs shows how cellular co-localization of circular RNAs can be imaged using circFISH. Read this paper in the Journal of Biological Chemistry 

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How does a bacterium flip its survival switch on and off?

This paper captures the first cryo-EM snapshots of the cyclic-di-AMP phosphodiesterase GdpP in three catalytic states, revealing the conformational switch that regulates bacterial stress signaling and pinpointing a druggable pocket for next-generation antibiotic adjuvants.

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